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Related Experiment Video

Updated: Jul 16, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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The Compound Terminalia Chebula Extract Alleviates PEDV-Induced Colonic Injury in Suckling Piglets by Enhancing

Yanyan Zhang1,2, Lingling Gan1,2, Muzi Li1,2

  • 1Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China.

Animals : an Open Access Journal From MDPI
|July 15, 2026
PubMed
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Metabolic reprogramming in the enterocytes of neonatal piglets infected with porcine epidemic diarrhea virus: integrated omics and multi-batch analysis highlight alterations in lipid metabolism and potential therapeutic targets.

Microbiology spectrum·2026

Compound *terminalia chebula* extract (HL) protects neonatal piglets from Porcine epidemic diarrhea virus (PEDV) by reducing colonic injury, inflammation, and viral replication. HL improves antioxidant capacity and regulates intestinal barrier function, offering a potential therapeutic strategy against PEDV.

Area of Science:

  • Veterinary Medicine
  • Gastroenterology
  • Virology

Background:

  • Porcine epidemic diarrhea virus (PEDV) causes significant enteric disease in neonatal piglets.
  • PEDV infection leads to colonic injury, disrupting intestinal homeostasis, barrier integrity, and ion transport.
  • The protective effects of *terminalia chebula* extract (HL) against PEDV-induced colonic damage are not well understood.

Purpose of the Study:

  • To evaluate the mitigating effects of HL on PEDV-induced colonic injury in piglets.
  • To elucidate the underlying molecular mechanisms of HL's protective action against PEDV.
  • To assess HL's impact on intestinal barrier function, oxidative stress, inflammation, and viral replication.

Main Methods:

  • Neonatal piglets were assigned to control, PEDV-infected, or HL-supplemented + PEDV-infected groups.
Keywords:
PEDVcolonic injurycompound terminalia chebula extractcrypt depthpiglets

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  • HL was administered orally, and PEDV challenge was performed on day 8 of the trial.
  • Colonic tissues were collected for histological examination and gene expression analysis of barrier integrity, oxidative stress, inflammation, and viral markers.

    • Main Results:

    • PEDV infection increased crypt depth, impaired barrier integrity (MMP7, MMP13), disorganized mucus (MUC5AC), induced oxidative stress (low CAT, high MDA), and triggered inflammation (REG3G, S100A8/A9, IL-1β).
    • PEDV also downregulated colonic ion transport genes (TRPV6, TRPM6).
    • HL supplementation reversed these effects, restoring morphology, enhancing antioxidant capacity, suppressing inflammation, modulating ion/water transport genes (AQP7, CLCA4, NHE3, TRPV6, TRPM6), and significantly inhibiting PEDV replication (M, N, S genes).

    Conclusions:

    • HL effectively alleviates PEDV-induced colonic tissue damage in piglets.
    • HL's protective mechanisms involve enhancing antioxidant capacity, mitigating inflammation, regulating intestinal barrier and ion/water transport genes, and inhibiting PEDV replication.
    • HL demonstrates potential as a therapeutic agent against PEDV infection in swine.