Related Experiment Video
Updated: Jul 16, 2026
09:57
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Routine Versus Clinically Indicated Replacement of Peripheral Intravenous Catheters in Adults: A Non-Inferiority
Nuri Kang1, Hyun Lim Kim1, Hye Ran Choi2
1Department of Nursing, Asan Medical Center, Seoul 05505, Republic of Korea.
Healthcare (Basel, Switzerland)
|July 15, 2026
Summary
Clinically indicated peripheral intravenous catheter (PIVC) replacement is as safe as routine replacement, showing non-inferiority for phlebitis. This approach reduces catheter insertions and extends dwell times, supporting its adoption in clinical practice.
Area of Science:
- Medical research
- Clinical trials
- Nursing practice
Background:
- Routine replacement of peripheral intravenous catheters (PIVCs) every 72-96 hours is standard practice.
- Guidelines increasingly support clinically indicated replacement, but evidence from Asian settings is limited.
Purpose of the Study:
- To evaluate the non-inferiority of clinically indicated PIVC replacement compared to routine replacement regarding phlebitis incidence.
- To assess secondary outcomes including catheter-related bloodstream infections, number of insertions, and dwell times.
Main Methods:
- A non-inferiority, cluster-randomised crossover trial involving 1324 adult participants in South Korea.
- Participants were allocated to either routine 96-hour replacement or clinically indicated replacement.
- The primary outcome was phlebitis incidence, with a non-inferiority margin of 5%.
Main Results:
- Phlebitis incidence was 12.6% in the clinically indicated group versus 11.7% in the routine group, meeting non-inferiority criteria (ARD 1.44 pp).
- No catheter-related bloodstream infections were reported in either group.
- The clinically indicated group had fewer catheter insertions (1.77 vs. 2.16) and longer dwell times (112.0 vs. 89.6 hours).
Conclusions:
- Clinically indicated PIVC replacement is non-inferior to routine replacement for preventing phlebitis.
- This strategy leads to fewer catheter insertions and longer dwell times.
- The findings support the implementation of clinically indicated PIVC replacement in healthcare settings.
Related Concept Videos
01:30Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:22Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
01:28Cardiac Catheterization I: Pre-Procedure Overview
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
01:26Cardiac Catheterization IV: Nursing Management
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...