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Updated: Jul 16, 2026
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Visualization of Intensity Levels to Reduce the Gap Between Self-Reported and Directly Measured Physical Activity
Published on: March 7, 2019
Association Between Physical Activity and Mortality in Men with or at Risk of Prostate Cancer: A Systematic Review
Nacho García-Miralles1, Irene Martínez-García2, Irene Marcilla-Toribio1,2,3
1Health and Social Research Center, University of Castilla-La Mancha, 16071 Cuenca, Spain.
Healthcare (Basel, Switzerland)
|July 15, 2026
Summary
Regular physical activity may lower all-cause mortality risk for men with or at risk of prostate cancer (PC). However, evidence for PC-specific mortality is inconsistent, and overall evidence certainty is very low.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Prostate cancer (PC) is a prevalent malignancy with significant mortality.
- Physical activity is linked to reduced PC risk and mortality, but evidence is limited.
- The association between physical activity and mortality in PC patients needs further investigation.
Purpose of the Study:
- To assess the association between physical activity and mortality risk in men with or at risk of prostate cancer.
- To synthesize existing observational data on physical activity and mortality outcomes in this population.
Main Methods:
- Systematic literature search of Medline, Scopus, and Web of Science.
- Inclusion of observational studies on physical activity and all-cause/PC-specific mortality.
- Data synthesis using a synthesis without meta-analysis (SWiM) approach; quality and certainty assessed using NHLBI and GRADE frameworks.
Main Results:
- Fifteen observational studies were included, predominantly using hazard ratios (HRs).
- Physical activity showed an association with reduced all-cause mortality (HRs: 0.40-0.88), with a dose-response gradient in some cohorts.
- Associations with PC-specific mortality were inconsistent, particularly in pre-diagnosis assessments; study quality and evidence certainty were generally very low.
Conclusions:
- Physical activity is associated with lower all-cause mortality in men with or at risk of PC, especially post-diagnosis.
- Evidence for PC-specific mortality is inconsistent and of very low certainty.
- Observational nature limits clinical recommendations; prospective studies with objective measures are needed.
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