Related Experiment Videos
Clinical Outcomes on Home Parenteral Support for Patients with Benign Chronic Intestinal Failure: Systematic Review
Maja Eckhardt1,2, Sorrel Burden1,2, Eilidh McGowan1
1Intestinal Failure Unit, Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
Nutrients
|July 15, 2026
Summary
Home parenteral support (HPS) for chronic intestinal failure (IF) shows a 33.5% mortality over ~4 years. Nutritional autonomy is achieved by 35.3% of patients, highlighting key factors for improved outcomes.
Area of Science:
- Gastroenterology and Hepatology
- Clinical Nutrition
- Outcomes Research
Background:
- Chronic intestinal failure (IF) is an end-stage condition requiring home parenteral support (HPS).
- Limited data exist on survival and nutritional autonomy in large, contemporary HPS-dependent cohorts.
- Understanding long-term outcomes is crucial for managing IF patients.
Purpose of the Study:
- To systematically review and meta-analyze survival and nutritional autonomy rates in adults with chronic IF receiving HPS.
- To provide updated, generalizable data on HPS outcomes up to 2025.
- To identify factors influencing mortality and nutritional autonomy.
Main Methods:
- Systematic review and meta-analysis of studies published up to February 2025.
- Inclusion of adult patients with benign chronic IF receiving HPS.
- Calculation of crude proportions and meta-analysis for annual rates; Kaplan-Meier curves for survival probabilities.
Main Results:
- Pooled 5-year survival rate: 68.71%; 10-year survival rate: 52.46%.
- Overall mortality: 8.0% per year (33.5% over ~4 years).
- Nutritional autonomy achieved by 35.3% of patients (10.0% per year); age, anatomy, and disease type are potential influencing factors.
Conclusions:
- This is the first systematic review and meta-analysis on survival and nutritional autonomy in adult chronic IF patients on HPS.
- Findings provide essential baseline data for clinical decision-making and patient counseling.
- Improved understanding of outcomes in this complex patient group is achieved.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...