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Specific Micronutrient Intake Association with Diabetic Neuropathy Severity in Adults with Type 2 Diabetes
Claudiu Cobuz1, Mădălina Ungureanu-Iuga2, Alina Cornea1
1Faculty of Medicine and Biological Sciences, Ştefan cel Mare University of Suceava, 13th Universităţii Street, 720229 Suceava, Romania.
Nutrients
|July 15, 2026
Summary
Specific nutrient intake, including protein, magnesium, zinc, and vitamins B3 and B12, is linked to reduced diabetic neuropathy severity in type 2 diabetes patients. Dietary patterns showed weaker associations after adjustments.
Area of Science:
- Endocrinology and Metabolism
- Nutritional Science
- Neurology
Background:
- Diabetic neuropathy is a common complication of type 2 diabetes mellitus (T2DM).
- The role of diet in diabetic neuropathy severity is not fully understood.
- This study focused on adults with T2DM in Northeastern Romania.
Purpose of the Study:
- To investigate the association between dietary patterns, nutrient intake, and diabetic neuropathy severity.
- To identify potential nutritional targets for managing diabetic neuropathy.
Main Methods:
- Dietary intake assessed via a food frequency questionnaire.
- Five dietary patterns identified using principal component analysis.
- Neuropathy severity analyzed using logistic regression, adjusted for key clinical factors.
Main Results:
- Western/fast-food and alcohol/animal fat diets showed associations with greater severity pre-adjustment.
- Higher protein, magnesium, zinc, vitamin B3, and vitamin B12 intake were independently associated with lower neuropathy severity.
- Adjusted analyses revealed nutrient intake as a stronger predictor than overall dietary patterns.
Conclusions:
- Specific nutrient intakes are more significantly associated with diabetic neuropathy severity than general dietary patterns.
- Highlights potential nutritional interventions for reducing neuropathy risk in T2DM.
- Suggests targeted nutritional strategies for clinical management of diabetic neuropathy.
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