Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An ECM-mimetic hydrogel for disc repair: reconstituting hypoxia and alleviating NPC senescence to halt intervertebral disc degeneration.

Journal of nanobiotechnology·2026
Same author

Protective Effects of Tuber sinoaestivum-Derived Exosome-Like Nanovesicles Against Cisplatin-Induced Acute Liver Injury and Acute Kidney Injury.

Journal of food science·2026
Same author

Divergent genetic and phenotypic trajectories in China' s maize hybrids.

BMC genomics·2026
Same author

Amino-Modified Mesoporous Bioactive Glass Adsorbed with Osteopontin Enhances Osteogenic Differentiation and Matrix Mineralization via the Erk1/2 Signaling Pathway.

Journal of functional biomaterials·2026
Same author

Delivery growth factors by layer-by-layer assembly in nanofibers for enhancing bone defect repairment along with neurogenesis.

International journal of biological macromolecules·2026
Same author

Sacral tilt: Novel parameters for predicting lumbar lordosis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026

Related Experiment Video

Updated: Jul 16, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Enhancing Bone Repair Process: Application and Perspective on Photothermal Materials.

Xuchen Yan1, Chuanpeng Zhou1, Hanyue Mao1

  • 1College of Science, National University of Defense Technology, Changsha 410073, China.

Molecules (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

Mild near-infrared photothermal therapy (PTT) offers a promising approach for bone defect repair by precisely controlling temperature to enhance healing. This method activates osteogenic signals and modulates the immune microenvironment for accelerated bone regeneration.

Keywords:
bone repairimmune regulationmild hyperthermiaphotothermal therapysequential repair

More Related Videos

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Related Experiment Videos

Last Updated: Jul 16, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Large bone defects present significant challenges in orthopedic treatment.
  • Near-infrared (NIR) photothermal therapy (PTT) is emerging as a novel strategy for bone regeneration, moving beyond tumor ablation.
  • Mild PTT (40-42 °C) promotes bone healing by stimulating osteogenic signals, regulating immune responses, and exhibiting antibacterial properties.

Purpose of the Study:

  • To review the applications of various photothermal conversion materials for mild PTT in bone repair.
  • To analyze the role of photothermal therapy in immune regulation and sequential repair strategies.
  • To discuss challenges and future directions for developing advanced smart bone repair materials.

Main Methods:

  • Review of existing literature on NIR-PTT for bone regeneration.
  • Analysis of photothermal materials including MXene, black phosphorus (BP), polydopamine/graphene oxide (PDA/GO), and metal-based nanomaterials.
  • Examination of studies focusing on temperature control, exposure duration, cell viability, and functional assessments of bone marrow-derived mesenchymal stem cells (BMSCs) and macrophages.

Main Results:

  • Mild PTT within a specific temperature window (40-42 °C) with controlled exposure (5-15 min) preserves cell viability (>85%) and osteogenic differentiation capacity.
  • Functional assessments confirm maintained macrophage plasticity after mild PTT.
  • Various photothermal materials demonstrate potential for effective bone regeneration applications.

Conclusions:

  • Precise temperature and duration control are critical for successful mild PTT in bone repair, avoiding apoptosis and necrosis.
  • Photothermal therapy shows potential for immune modulation and sequential repair strategies.
  • Further research into smart materials and therapeutic strategies is needed to advance bone regeneration.