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Related Experiment Video

Updated: Jul 16, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

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Published on: August 1, 2025

Acute Toxicity of Three Synthetic Cannabinoids: First In Vivo Preclinical Study.

Silviu-Iulian Filipiuc1, Carmen Solcan2, Bogdan-Ionel Tamba1,3

  • 1Advanced Research and Development Center for Experimental Medicine "Prof. Ostin C. Mungiu"-CEMEX, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.

Molecules (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

This study screened three synthetic cannabinoids (SCs) in mice, revealing distinct acute toxicity profiles. MAB-CHMINACA showed significant central nervous system effects, while JWH-007 and AM-694 exhibited other organ-specific changes.

Keywords:
AM-694JWH-007MAB-CHMINACAacute in vivo toxicitynew psychoactive substancessynthetic cannabinoidssynthetic cannabinoids with abuse potential

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Last Updated: Jul 16, 2026

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Area of Science:

  • Toxicology
  • Pharmacology
  • Neuroscience

Background:

  • Synthetic cannabinoids (SCs) are emerging psychoactive substances frequently linked to acute intoxications.
  • Limited experimental data exists for characterizing the acute toxicity of SCs under controlled conditions.

Purpose of the Study:

  • To characterize the acute toxicity profile of three specific SCs: JWH-007, AM-694, and MAB-CHMINACA.
  • To generate hypotheses for future, more detailed toxicological investigations of SCs.

Main Methods:

  • Acute toxicity was assessed in female Swiss Albino mice following OECD 423 guidelines.
  • Oral and intraperitoneal administration routes were used, with 14-day monitoring for clinical and behavioral signs.
  • Histopathological examination and serum concentration analysis (LC-ESI-MS/MS) were conducted.

Main Results:

  • JWH-007 induced transient behavioral depression and peripheral organ histopathology.
  • AM-694 caused systemic organ histopathological changes with minimal behavioral effects.
  • MAB-CHMINACA was associated with acute behavioral toxicity and central nervous system lesions, including neuronal damage and inflammation.

Conclusions:

  • Preliminary findings highlight compound-specific in vivo toxicity patterns for JWH-007, AM-694, and MAB-CHMINACA.
  • Observed changes are hypothesis-generating and require statistical validation for comparative toxicity assessments.
  • These results may guide future research on SC toxicity and risk stratification.