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Updated: Jul 16, 2026

Radio Frequency Magnetron Sputtering of GdBa2Cu3O7−δ/ La0.67Sr0.33MnO3 Quasi-bilayer Films on SrTiO3 (STO) Single-crystal Substrates

Radio Frequency Magnetron Sputtering of GdBa₂Cu₃O₇₋_δ/ La_0.67Sr_0.33MnO₃ Quasi-bilayer Films on SrTiO₃ (STO) Single-crystal Substrates

Published on: April 12, 2019

Advances in Materials for Strontium-Yttrium Separation: A Comprehensive Review.

Mali Xu¹, Zhimin Wang¹, Tong Zhang¹

¹Department of Radiochemistry and Engineering, China Institute of Atomic Energy, P.O. Box 275-88, Beijing 102413, China.

Materials (Basel, Switzerland)

|July 15, 2026

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Efficient separation of Yttrium-90 (⁹⁰Y) from its radioactive parent Strontium-90 (⁹⁰Sr) is crucial for cancer therapy. This review highlights advanced adsorbent materials for high-efficiency ⁹⁰Y production, ensuring safer clinical applications.

Area of Science:

Radiochemistry
Materials Science
Nuclear Medicine

Background:

Yttrium-90 (⁹⁰Y) is a key radionuclide for targeted cancer therapy (e.g., hepatocellular carcinoma, lymphoma).
The ⁹⁰Sr-⁹⁰Y generator is the primary method for producing no-carrier-added (NCA) ⁹⁰Y.
Strict separation of the radiotoxic parent ⁹⁰Sr is essential due to its bone-seeking nature and long half-life.

Purpose of the Study:

To review recent advancements in solid-phase adsorbent materials for Y³⁺/Sr²⁺ separation.
To analyze design strategies, recognition mechanisms, and performance of functional separation systems.
To provide an outlook on next-generation ⁹⁰Sr-⁹⁰Y generator materials.

Main Methods:

Keywords:

90Sr-90Y generators adsorbent materials extraction chromatography ion exchange resins medical isotopes

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Discussion of extraction chromatography (EXC) resins (organophosphorus extractants, diglycolamide derivatives, crown ethers).

Analysis of inorganic ion exchangers (antimony-based materials, manganese oxides, zeolite-like molecular sieves).

Evaluation of composite modification strategies (silica/polymer composites, metal doping) for enhanced properties.

Main Results:

Various adsorbent materials demonstrate high efficiency in separating Y³⁺ from Sr²⁺.
Composite materials and metal doping enhance radiation resistance, acid stability, and separation factors (SF).
Current materials show promise for improving the safety and efficacy of ⁹⁰Y-based therapies.

Conclusions:

Significant progress has been made in developing advanced materials for ⁹⁰Sr-⁹⁰Y separation.
Optimized materials are crucial for meeting clinical demands for NCA ⁹⁰Y.
Future research should focus on transitioning laboratory findings to robust, field-ready generator applications.