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Updated: Jul 16, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Gentamicin-Loaded Electrospun PVA/Kefiran/Schizophyllan Membrane for Skin Tissue Engineering Applications.

Karla Katiushka Solís-Arévalo1, Luis J Galán-Wong1, Aida Rodriguez-Garcia1

  • 1Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Instituto de Biotecnología, Ciudad Universitaria, Av. Pedro de Alba S/N, San Nicolás de los Garza C.P. 66455, Nuevo León, Mexico.

Polymers
|July 15, 2026
PubMed
Summary

New electrospun membranes offer a promising solution for wound care, reducing skin damage and infection risk. These biocompatible materials show significant antimicrobial activity and are safe for skin cells.

Keywords:
biopolymerdrug deliveryelectrospinningnanofibersskin tissue engineeringwound dressing

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Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Regenerative Medicine

Background:

  • Healthcare-associated infections are a significant concern in clinical settings.
  • Traditional wound dressings can damage the skin barrier upon removal.
  • Novel biomaterials are needed for advanced wound management.

Purpose of the Study:

  • To develop and characterize an electrospun membrane for wound dressing applications.
  • To incorporate gentamicin and ascorbic acid for enhanced therapeutic effects.
  • To evaluate the antimicrobial and cytocompatibility properties of the novel membrane.

Main Methods:

  • Electrospinning of polyvinyl alcohol, kefiran, and schizophyllan.
  • Loading the membrane with gentamicin and ascorbic acid.
  • Assessing antimicrobial activity against *Staphylococcus aureus* and *Pseudomonas aeruginosa*.
  • Evaluating cytocompatibility using human dermal fibroblasts (HDFn cells).

Main Results:

  • Beadless electrospun membranes with a 400 nm diameter were successfully produced.
  • Significant antimicrobial activity was observed against *Pseudomonas aeruginosa* (16.4 ± 2.2 mm inhibition halos).
  • The membrane demonstrated no cytotoxicity to human dermal fibroblasts, indicating good biocompatibility.

Conclusions:

  • The developed electrospun membrane exhibits potent antimicrobial properties and excellent cytocompatibility.
  • This novel biomaterial holds significant potential for future wound dressing applications.
  • The study highlights a promising advancement in managing skin wounds and preventing infections.