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Patient-Reported Outcomes and Functional Recovery After Treatment for Laryngeal Cancer: A Scoping Review of
Ion Costel Epuraș1,2, Alexandru Florian Crișan3,4, Nicolae Constantin Balica2,5
1Doctoral School, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Journal of Clinical Medicine
|July 15, 2026
Summary
Patient-reported outcome measures (PROMs) in laryngeal cancer research primarily focus on voice, with limited integration of objective data. Standardized, multidimensional frameworks are needed for better survivorship care.
Area of Science:
- Oncology
- Rehabilitation Medicine
- Health Outcomes Research
Background:
- Laryngeal cancer treatment significantly impacts patient quality of life, including voice, swallowing, and communication.
- Patient-reported outcome measures (PROMs) are crucial for assessing survivorship but show varied application and integration with objective data.
- Current research lacks a comprehensive understanding of how PROMs align with objective functional outcomes in laryngeal cancer survivors.
Purpose of the Study:
- To explore the utilization of PROMs in laryngeal cancer research.
- To identify functional domains assessed by PROMs and their relationship with objective clinical outcomes.
- To pinpoint methodological gaps in current laryngeal cancer survivorship studies.
Main Methods:
- A scoping review adhering to PRISMA-ScR guidelines was conducted.
- Searches included PubMed/MEDLINE, Scopus, and Web of Science up to April 2026.
- Data extraction focused on study characteristics, PROM tools, assessed domains, and PROM-objective outcome links.
Main Results:
- Ninety-five studies involving 10,807 participants were analyzed, predominantly observational and single-center.
- Voice (86.3%), psychological (72.6%), and swallowing (65.3%) outcomes were most frequently assessed.
- Over half of studies lacked statistical integration between PROMs and objective measures (51.6%), with limited analytical integration (13.7%).
Conclusions:
- PROM application in laryngeal cancer survivorship research is heterogeneous, with a strong emphasis on voice-related outcomes.
- The limited integration of PROMs with objective measures hinders a holistic understanding of patient recovery.
- Standardized, multidimensional assessment frameworks incorporating functional, nutritional, psychosocial, and objective data are essential for patient-centered care.
