Hyaluronic Acid Fillers Versus Polynucleotides for Under-Eye Rejuvenation

Area of Science:

• Aesthetic Medicine
• Dermatology
• Regenerative Medicine

Background:

• The periorbital region presents unique challenges for aesthetic treatments due to delicate skin and vascularity.
• Hyaluronic acid (HA) fillers are standard for volume but have limitations in skin quality improvement and potential complications.
• Polynucleotides (PN), specifically polydeoxyribonucleotides (PDRN), are emerging as regenerative agents with potential for dermal repair.

Purpose of the Study:

• To critically review and compare the efficacy and safety of Polynucleotides (PN) versus Hyaluronic Acid (HA) in periorbital rejuvenation.
• To integrate mechanistic data, clinical outcomes, and safety profiles of both treatment modalities.
• To identify research gaps and suggest future directions for PN and HA in aesthetic medicine.

Main Methods:

• Systematic review of current scientific literature comparing PN and HA for periorbital rejuvenation.
• Analysis of studies focusing on mechanistic actions, clinical results, and adverse events.
• Evaluation of evidence regarding skin quality parameters and structural correction.

Main Results:

• Hyaluronic acid (HA) remains the preferred choice for structural and volumetric correction in the periorbital area.
• Polynucleotides (PN) demonstrate significant improvements in skin elasticity, hydration, and reduction of fine rhytids.
• PN exhibit a favorable safety profile with fewer reported complications compared to HA in this context.

Conclusions:

• PN offer a promising regenerative alternative for improving periorbital skin quality, complementing HA's structural benefits.
• Further high-quality, standardized research, including direct comparative trials, is necessary to establish definitive treatment protocols.
• Optimal treatment algorithms integrating PN and HA may provide comprehensive periorbital rejuvenation.