Routine Haematological Parameters Associated with HbA1c and Estimated Whole-Blood Viscosity in Diabetes Management:...

Area of Science:

• Hematology
• Diabetology
• Clinical Chemistry

Background:

• Routine full blood count (FBC) testing is integral to diabetes management.
• Limited data exists on how individual FBC parameters contribute to models predicting glycated haemoglobin (HbA1c) and estimated whole-blood viscosity (eWBV).
• This study explores comparative and predictive relationships between FBC parameters and diabetes markers.

Purpose of the Study:

• To compare FBC parameters between diabetic groups with high and low HbA1c and eWBV.
• To identify FBC variables that contribute to AIC-based regression models for HbA1c and eWBV.
• To explore the predictive potential of FBC parameters in diabetes.

Main Methods:

• Cross-sectional and regression analyses of 15 FBC parameters.
• Creation of dichotomous subgroups based on HbA1c and eWBV levels for univariate comparison.
• Exploratory Akaike Information Criterion (AIC)-based model identification of contributing variables.

Main Results:

• Red cell distribution width (RDW), mean corpuscular volume (MCV), red cell distribution width-to-platelet count ratio (RPR), mean corpuscular haemoglobin (MCH), and red blood cell count (RBC) significantly contributed to the HbA1c model.
• Haematocrit (HCT), haemoglobin (HB), RBC, white blood cell count (WBC), and mean lymphocyte ratio (MLR) showed significant associations with eWBV.
• RDW, MCV, and RPR differed significantly between HbA1c groups.

Conclusions:

• Selected FBC parameters demonstrate potential for developing future predictive models in diabetes.
• These FBC variables can serve as adjuncts in diabetes monitoring.
• The findings support the utility of FBC in understanding glycaemia control and blood viscosity complications.