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Updated: Jul 16, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

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Published on: March 26, 2020

Optical Coherence Tomography Biomarkers in Rhegmatogenous Retinal Detachment: A Narrative Review.

Vladimir Milutinovic¹, Borivoje Savic¹, Jelena Kostic¹

¹Clinic for Eye Diseases, University Clinical Center of Serbia, 11000 Belgrade, Serbia.

Journal of Clinical Medicine

|July 15, 2026

Summary

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Optical coherence tomography (OCT) identifies biomarkers predicting visual recovery after rhegmatogenous retinal detachment (RRD) repair. Outer retinal integrity, specifically the ellipsoid zone (EZ) and external limiting membrane (ELM), is key for successful visual outcomes.

Area of Science:

Ophthalmology
Retinal Imaging
Vision Science

Background:

Rhegmatogenous retinal detachment (RRD) is a serious condition where anatomical success doesn't guarantee visual recovery.
Optical coherence tomography (OCT) is crucial for assessing retinal microstructure and predicting visual outcomes post-RRD repair.

Purpose of the Study:

To review and evaluate the prognostic significance of OCT biomarkers after RRD repair.
To identify key OCT indicators for predicting postoperative visual acuity.

Main Methods:

Narrative review of existing literature on OCT biomarkers in RRD.
Critical evaluation of studies assessing the relationship between OCT findings and visual outcomes.

Main Results:

Keywords:

OCT biomarkers ellipsoid zone epiretinal membrane external limiting membrane optical coherence tomography retinal imaging rhegmatogenous retinal detachment visual prognosis

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Last Updated: Jul 16, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Outer retinal biomarkers, including ellipsoid zone (EZ) and external limiting membrane (ELM) integrity, are the strongest predictors of best-corrected visual acuity.

Secondary biomarkers (e.g., hyperreflective foci, subretinal fluid) offer complementary prognostic information on inflammation and complications.

Conclusions:

OCT biomarkers, particularly outer retinal integrity, are valuable for predicting visual recovery after RRD repair.
Standardization of OCT assessment criteria and further validation in prospective studies are needed for routine clinical use.