Association Between Female Reproductive Factors and Laryngopharyngeal Reflux: A National Population-Based Study

Area of Science:

• Reproductive Health
• Gastroenterology
• Epidemiology

Background:

• The connection between female reproductive factors and laryngopharyngeal reflux (LPR) is not well-established.
• This study aims to explore the relationship between reproductive history and LPR risk in women.

Purpose of the Study:

• To investigate the association between various female reproductive factors and the risk of developing laryngopharyngeal reflux (LPR).
• To identify specific reproductive history elements that may increase LPR susceptibility in women.

Main Methods:

• A nested case-control study utilized data from the Korean National Health and Nutrition Examination Survey and National Health Insurance Service (2007-2017).
• Propensity score matching identified 1347 LPR cases and 1347 controls, adjusting for age, income, and education.
• Multivariable logistic regression analyzed associations between reproductive factors and LPR risk, controlling for metabolic and lifestyle variables.

Main Results:

• First childbirth at age 27 or later was associated with a significantly higher LPR risk (aOR 1.33).
• A longer interval between menarche and first birth (≥17 years) increased LPR risk (aOR 1.56).
• Breastfeeding duration under 12 months independently correlated with a higher LPR risk (aOR 1.26).

Conclusions:

• Female reproductive factors, potentially indicating cumulative hormonal influences, are independently linked to LPR risk.
• Reproductive history elements including late first delivery, extended menarche-to-birth interval, and limited breastfeeding duration are associated with LPR.
• Reproductive history should be considered in the clinical evaluation of women presenting with reflux-related symptoms.