Dynamic Changes in Peripheral Nerve Stiffness After Regional Anesthesia: Implications of Shear Wave Elastography in...

Adductor canal block (ACB) is widely used for perioperative analgesia in knee surgery because it provides effective pain control while preserving quadriceps muscle strength. With the increasing use of ultrasound-guided regional anesthesia, interest has expanded beyond conventional morphologic imaging toward quantitative assessment of peripheral nerve function and biomechanics. Shear wave elastography (SWE) is an emerging ultrasound-based technique that enables real-time quantification of tissue stiffness and has recently gained attention in peripheral nerve evaluation. Previous SWE studies have primarily focused on chronic neuropathic conditions, including entrapment neuropathy and diabetic neuropathy, in which increased nerve stiffness is commonly observed. However, emerging observations suggest that peripheral nerve stiffness may dynamically decrease following regional anesthesia procedures such as ACB. This finding raises the possibility that nerve stiffness reflects not only chronic structural pathology but also transient physiologic and biomechanical modulation. Potential mechanisms underlying reduced stiffness after ACB include perineural hydrodissection, decreased fascial compression, sympathetic blockade-induced vasodilation, altered intraneural pressure, and changes in surrounding muscle tension. Because the saphenous nerve within the adductor canal is superficial and consistently visualized under ultrasound guidance, ACB represents an attractive model for investigating dynamic changes in peripheral nerve biomechanics. This narrative review summarizes current evidence regarding SWE assessment of peripheral nerves and discusses the potential implications of dynamic stiffness changes after regional anesthesia. We review the biomechanical principles of SWE, factors affecting nerve stiffness, current evidence in neuropathic and perioperative settings, technical limitations, and future clinical applications. Understanding the dynamic behavior of peripheral nerve stiffness may expand the role of SWE from a diagnostic tool for neuropathy to a quantitative biomarker for regional anesthesia and perioperative nerve physiology.