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Related Experiment Video

Updated: Jul 16, 2026

Early Unguided Human Brain Organoid Neurovascular Niche Modeling into the Permissive Chick Embryo Chorioallantoic Membrane
04:08

Early Unguided Human Brain Organoid Neurovascular Niche Modeling into the Permissive Chick Embryo Chorioallantoic Membrane

Published on: February 16, 2024

Vascularized Brain Organoids: Advances in Engineering Human Neurovascular Models.

Hee Young Kim1, Jung Eun Lee2, Seung Ho Yang1

  • 1Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

International Journal of Stem Cells
|July 15, 2026
PubMed
Summary

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Vascularized brain organoids (vBOs) are engineered to mimic human neurovascular interactions, improving disease modeling and drug screening for neurological disorders. Challenges remain in achieving mature neurovascular features for translational research.

Area of Science:

  • Neuroscience
  • Biotechnology
  • Developmental Biology

Background:

  • Brain organoids are crucial for studying neurodevelopment and neurological disorders.
  • Current brain organoids lack functional vascular networks, limiting physiological relevance.
  • Vascularized brain organoids (vBOs) aim to recapitulate neurovascular interactions.

Purpose of the Study:

  • To review current strategies for engineering vascularized brain organoids (vBOs).
  • To discuss the potential implications of vBOs in disease modeling, drug screening, and regenerative therapies.
  • To identify persistent challenges in achieving mature neurovascular features in vBOs.

Main Methods:

  • Literature review of current vBO engineering strategies.
  • Analysis of potential applications and limitations of vBO technology.
Keywords:
Blood-brain barrierCerebrovascular disordersNeurovascular couplingOrganoidsPluripotent stem cells

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Last Updated: Jul 16, 2026

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Published on: February 16, 2024

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Published on: July 21, 2023

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  • Discussion of the evolving framework for neurovascular modeling.

    • Main Results:

    • vBO engineering is a rapidly evolving field.
    • vBOs offer enhanced potential for disease modeling and drug screening.
    • Significant challenges persist in replicating mature neurovascular complexity.

    Conclusions:

    • vBOs represent a significant advancement in modeling neurovascular interactions.
    • Further research is needed to overcome challenges in achieving physiological maturity.
    • vBOs hold promise for translational research in neurological disorders.