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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
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Published on: January 9, 2019

Lymphomatoid papulosis: a practical review for pathologists.

Mario L Marques-Piubelli1, Carlos A Torres-Cabala2, Roberto N Miranda3

  • 1The Healthcare Business of Merck KGaA, Darmstadt, Germany.

Journal of Pathology and Translational Medicine
|July 15, 2026
PubMed
Summary

Lymphomatoid papulosis (LyP) is a skin disorder with recurrent, self-healing lesions. Diagnosis relies on CD30 positivity, but subtypes do not alter prognosis or treatment, focusing on symptom relief.

Keywords:
Anaplastic large cell lymphomaCD30Cutaneous lymphomaDUSP22Lymphomatoid papulosisPrimary cutaneous ALCL

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Area of Science:

  • Dermatology
  • Hematology
  • Pathology

Background:

  • Lymphomatoid papulosis (LyP) is a primary cutaneous CD30+ lymphoproliferative disorder.
  • Characterized by chronic, recurrent, self-healing skin lesions (papules/nodules).
  • Exhibits an indolent clinical course with spontaneous regression or waxing/waning evolution.

Purpose of the Study:

  • To review updated clinical, histopathological, and molecular features of LyP.
  • To provide practical diagnostic assessment for differential diagnoses.
  • To summarize current understanding of LyP subtypes and their implications.

Main Methods:

  • Literature review of clinical, histopathological, and molecular data on LyP.
  • Analysis of diagnostic criteria, including CD30 positivity.
  • Examination of LyP subclassification (A-E) and associated molecular findings (DUSP22/IRF4).

Main Results:

  • LyP diagnosis is based on CD30 positivity, with a broad histopathologic spectrum.
  • Subclassification (A-E) is associated with DUSP22/IRF4 rearrangements but does not impact prognosis.
  • Treatment focuses on symptom relief and regression, irrespective of subtype.

Conclusions:

  • LyP is a CD30+ lymphoproliferative disorder with variable histology but consistent clinical behavior.
  • Subtyping aids in differential diagnosis awareness but not in prognostic or therapeutic decisions.
  • Accurate diagnosis and understanding of LyP characteristics are crucial for patient management.