Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 16, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Interleukin 32 Expression in Mesothelioma.

Takuya Mikamo1,2, Riko Niwa2,3, Yuki Hanamatsu1

  • 1Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu, Japan.

Thoracic Cancer
|July 15, 2026
PubMed
Summary

Interleukin 32 (IL32) is present in epithelioid mesothelioma and may promote tumor development. Downregulating IL32 increases cancer cell death, suggesting a role in mesotheliomagenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model.

Biochemistry and biophysics reports·2026
Same author

A rare case of thymoma with extensive clear cell components: a discussion of its clear cell transformation.

Medical molecular morphology·2025
Same author

Bronchiolar Adenoma/Ciliated Muconodular Papillary Tumour With a 17-Year Follow-Up: A Case Report.

Respirology case reports·2025
Same author

Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland.

Discover oncology·2025
Same author

Epithelial-Mesenchymal Plasticity in the D-Meso-Sonobe Mesothelioma Cell Line: A Putative Model of Epithelial-Mesenchymal Transition in Mesothelioma.

Thoracic cancer·2025
Same author

Expression of the Niemann-Pick C1-like 1 Protein in Gastric Cancer.

Anticancer research·2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Interleukin 32 (IL32) has varied roles in cancer development.
  • Its specific function in mesothelioma, a rare cancer, requires further investigation.

Purpose of the Study:

  • To investigate the expression and functional role of Interleukin 32 (IL32) in mesothelioma.
  • To explore IL32's potential contribution to mesotheliomagenesis.

Main Methods:

  • Immunohistochemistry and immunoblot analysis were used to assess IL32 protein expression in mesothelioma tissues and cell lines.
  • Functional studies involved ectopic expression of IL32 isoforms and siRNA-mediated IL32 knockdown.

Main Results:

  • IL32 expression was detected in epithelioid mesothelioma tissues and cell lines, but not significantly in sarcomatoid types.
Keywords:
IL32carcinogenesisimmunohistochemistrymesothelioma

More Related Videos

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Related Experiment Videos

Last Updated: Jul 16, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

  • IL32θ isoform suppressed epithelioid to sarcomatoid transition, while IL32 downregulation increased apoptosis.
  • IL32 inhibited expression of SPARC, an epithelial-mesenchymal transition-related protein.

    • Conclusions:

    • Interleukin 32 (IL32) is expressed in epithelioid mesothelioma.
    • IL32 may play a role in the development and progression of mesothelioma.