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Updated: Jul 16, 2026

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Human Platelet-Derived Extracellular Vesicles Are Internalized by Human Induced Pluripotent Stem Cell-Derived Neurons

Venla Harju1, Kai Härkönen2, Ulla Impola2

  • 1NeuroGroup, Faculty of Medicine and Health Technology Tampere University Tampere Finland.

Journal of Extracellular Biology
|July 15, 2026
PubMed
Summary

Human platelet-derived extracellular vesicles (EVs) show potential for stroke treatment by enhancing neuronal activity after hypoxic injury. These EVs are internalized by neurons and may aid in recovery and neuroprotection.

Keywords:
acute strokeextracellular vesicleshypoxiain vitromicroelectrode arrayneuron

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...