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Updated: Jul 16, 2026
06:58
Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Malnutrition, Frailty, and High Fall Risk in Older Adults: Examining Their Interactive Effects in a Cross-Sectional
Honghong Wen1,2, Heting Liang1, Qingyun Mao2
1Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China.
Clinical Interventions in Aging
|July 15, 2026
Summary
Falls are a significant public health issue for seniors. This study found that frailty and malnutrition together significantly increase fall risk in older adults, highlighting the need for combined prevention strategies.
Area of Science:
- Gerontology
- Public Health
- Epidemiology
Background:
- Falls represent a critical public health challenge for the elderly population.
- Frailty and malnutrition are known risk factors for falls, but their combined impact is not well understood.
Purpose of the Study:
- To investigate the interactive effects of frailty and malnutrition on fall risk in older adults.
- To quantify the combined risk associated with co-occurring frailty and malnutrition.
Main Methods:
- 13,970 older adults were recruited from 10 communities.
- Participants were assessed using frailty scores, the Mini-Nutritional Assessment Scale, and the STEADI tool.
- Logistic regression and interaction analyses (RERI, AP, SI) were used to evaluate multiplicative and additive interactions.
Main Results:
- 24.1% of participants had a high fall risk.
- Co-existing frailty and malnutrition significantly increased odds of high fall risk (OR = 15.83).
- Significant positive multiplicative (OR = 1.064) and additive interactions (RERI = 1.58, SI = 1.18) were observed.
Conclusions:
- Frailty and malnutrition are independently associated with increased fall risk in older adults.
- A modest positive interaction exists between frailty and malnutrition regarding fall risk.
- Findings support integrated strategies for fall prevention and management in the elderly.
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