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Updated: Jul 16, 2026
07:02
Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
Sonodynamic CoMg-Quercetin Nanozyme for Antibacterial Therapy and Multifunctional Bone Regeneration in Infectious
Yurong Xu1,2, Jingyu Yan1,2, Lihong Zhou1,2
1Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China.
Biomaterials Research
|July 15, 2026
Summary
A new nanozyme, CoMg-Que, effectively treats infectious bone defects by combining antibacterial action with inflammation reduction. This breakthrough promotes significant bone regeneration, offering a promising solution for challenging bone injuries.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Infectious bone defects pose significant clinical challenges due to inflammation hindering bone regeneration.
- Current treatments struggle to simultaneously address infection and promote healing.
Purpose of the Study:
- To engineer a multifunctional nanozyme (CoMg-Que) for treating infectious bone defects.
- To integrate antibacterial therapy, redox modulation, and tissue regeneration into a single platform.
Main Methods:
- CoMg-Que nanozyme synthesized and characterized.
- In vitro evaluation of antibacterial, immunomodulatory, pro-angiogenic, and osteogenic properties.
- In vivo assessment in a methicillin-resistant Staphylococcus aureus (MRSA)-infected rat calvarial defect model.
Main Results:
- CoMg-Que demonstrated efficient sonodynamic generation of reactive oxygen species (ROS) for antibacterial treatment upon ultrasound irradiation.
- Post-treatment, CoMg-Que's intrinsic enzyme-like activities neutralized excess ROS, reducing inflammation and restoring redox balance.
- In vitro studies showed effective MRSA elimination and beneficial effects on angiogenesis and osteogenesis.
- In vivo, CoMg-Que achieved 95.24% antibacterial efficiency and significantly enhanced bone regeneration (26.76% bone volume fraction).
Conclusions:
- CoMg-Que is a promising multifunctional platform for infectious bone defect treatment.
- The nanozyme coordinates antibacterial, immunoregulatory, and regenerative activities for enhanced therapeutic outcomes.
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