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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke
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AAV Systems and Mouse Models for Investigating Ectopic Expression of Neurod1 in Transduced Cells at Subacute and Chronic Times Post-Ischemic Stroke

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Reprogramming the spleen-brain axis: Splenic monocyte/macrophage-mediated nanotherapy for ischemic stroke

Xiaodi Shi1, Rabeya Jafrin Mow1, Chunhua Yang1,2

  • 1Institute for Biomedical Sciences, Center for Inflammation, Immunity & Infection, Digestive Disease Research Group, Georgia State University, Atlanta, GA 30303, USA.

Acta Pharmaceutica Sinica. B
|July 15, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
CCR2/CCL2Macrophage reprogrammingMagnololNanomedicineOxidative stressPPARγ

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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