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Updated: Jul 16, 2026
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A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
Published on: April 25, 2015
Rgg/SHP transcriptional regulators, RaS-RiPPs, and their impacts in streptococci
Sristi Dey1, Sophie A Krivograd1, Britta E Rued1
1Veterinary Microbiology and Preventive Medicine, Iowa State University College of Veterinary Medicine, Ames, Iowa, 50010, USA.
F1000Research
|July 15, 2026
Summary
Streptococci utilize Rgg/SHP quorum sensing systems to control various cellular functions and produce natural products called RaS-RiPPs. This review explores these systems, their connection to RaS-RiPPs, and their role in streptococcal biology.
Area of Science:
- Microbiology
- Molecular Biology
- Biochemistry
Background:
- Streptococci are common microbes in human and animal microbiomes.
- Rgg transcriptional regulators and their peptide signals (SHPs and LCPs) are key to streptococcal communication.
- Rgg/SHP quorum sensing (QS) systems regulate vital cellular processes including virulence and metabolism.
Purpose of the Study:
- To review Rgg/SHP systems in streptococci.
- To explore the characteristics and functions of RaS-RiPPs (Radical S-adenosylmethionine enzyme Ribosomally translated and Post-translationally modified Peptides).
- To elucidate the link between Rgg/SHP systems and RaS-RiPP production.
Main Methods:
- Literature review and synthesis of existing research on Rgg/SHP systems and RaS-RiPPs.
- Analysis of the regulatory mechanisms connecting Rgg/SHP systems to natural product biosynthesis.
- Overview of streptococcal competence in relation to peptide signaling.
Main Results:
- Rgg/SHP QS systems are widespread in streptococci, controlling diverse cellular activities.
- These systems regulate the production of RaS-RiPPs, a diverse group of natural products with varied functions.
- Sixteen RaS-RiPP subfamilies have been identified, some with known inhibitory properties.
Conclusions:
- Rgg/SHP systems play a crucial role in regulating streptococcal behavior and natural product synthesis.
- The connection between Rgg/SHP systems and RaS-RiPPs highlights a significant regulatory network in streptococci.
- Understanding these systems offers insights into streptococcal colonization, virulence, and potential therapeutic applications.
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