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ZIF-4 exhibiting high carbonic anhydrase-mimicking activities
Teng Zhang1, Binying Qiu1, Xiaogui Lin1
1Guilin University of Technology, College of Chemistry and Bioengineering Guilin Guangxi 541006 China clei@glut.edu.cn.
RSC Advances
|July 15, 2026
Summary
This study introduces ZIF-4 as a novel carbonic anhydrase (CA)-mimicking nanozyme for efficient carbon dioxide (CO2) fixation. ZIF-4 demonstrates superior CA-mimicking activity compared to ZIF-8, offering a promising green strategy for waste-to-resource utilization.
Area of Science:
- Materials Science
- Biochemistry
- Environmental Science
Background:
- Carbon dioxide (CO2) fixation using carbonic anhydrase (CA) is a key strategy for waste-to-resource utilization.
- Developing efficient and stable CA mimics is crucial for environmental applications.
Purpose of the Study:
- To synthesize and characterize ZIF-4 as a CA-mimicking nanozyme.
- To evaluate the CO2 hydration activity of ZIF-4.
- To compare the CA-mimicking performance of ZIF-4 with ZIF-8.
Main Methods:
- Convenient synthesis of ZIF-4 using zinc and imidazole.
- CO2 hydration reaction for activity assessment.
- Quantitative evaluation of CA-mimicking activity using an esterase activity-based method with p-nitrophenyl acetate (p-NPA) as substrate.
Main Results:
- ZIF-4 was successfully synthesized and confirmed to possess CA-mimicking nanozyme properties.
- ZIF-4 exhibited significantly higher CA-mimicking activities than ZIF-8.
- Doped ZIF-8 with 2-methylimidazole showed lower activity compared to ZIF-4.
Conclusions:
- ZIF-4 is a highly effective CA-mimicking nanozyme for CO2 fixation.
- ZIF-4 presents a promising green and environmentally friendly approach for CO2 capture and utilization.
- The study highlights ZIF-4 as a superior alternative to ZIF-8 for CA-mimicking applications.
