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Published on: September 20, 2018

Apremilast for acquired reactive perforating collagenosis with metabolic and infectious comorbidities: a case report

Fujun Huang1,2, Lei Tang1,3, Mengya Huang1

  • 1Department of Cosmetic Dermatology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.

Frontiers in Immunology
|July 15, 2026
PubMed

Insights

Acquired reactive perforating collagenosis (ARPC) treatment with apremilast showed rapid symptom improvement. This therapy offers a safe option for patients unable to use standard immunosuppressants, with lasting effects.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder with no established treatment.
  • Patients often have comorbidities like diabetes, increasing treatment challenges.
Keywords:
acquired reactive perforating collagenosisapremilastcase reportcomorbiditiestreatment

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