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Retroperitoneal Fibrosis with Pancreatic, Colonic Involvement Mimicking Malignancy: A Case Report.
Saeed Aldarwish1, Anne-Sophie Becker2, Imad Kamaleddine1
1Department of Surgery, University Medical Center Rostock, Rostock, Germany.
Visceral Medicine
|July 15, 2026
Summary
IgG4-related retroperitoneal fibrosis (IgG4-related RPF) can rarely mimic colon cancer, presenting as acute bowel obstruction. This case highlights the importance of considering benign inflammatory conditions to avoid misdiagnosis and overtreatment.
Area of Science:
- Gastroenterology
- Pathology
- Surgical Oncology
Background:
- IgG4-related retroperitoneal fibrosis (IgG4-related RPF) is a rare systemic fibro-inflammatory disorder.
- It can present as a mass-forming lesion, often mimicking malignancy.
- Gastrointestinal involvement is uncommon, with acute large bowel obstruction being exceedingly rare.