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Case Report: Trazodone as a possible treatment for psychiatric adverse events related to ALK inhibitors

Luca Persico1, Andrea Miuli1,2, Stefania Chiappini1,3

  • 1Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi G. D'Annunzio, Chieti, Italy.

Frontiers in Psychiatry
|July 15, 2026
PubMed
Abstract

Insights

This study details successful trazodone treatment for lorlatinib-induced psychiatric symptoms in ALK-positive lung cancer patients. It proposes a management strategy for these common adverse events.

Area of Science:

  • Oncology
  • Psychiatry
  • Pharmacology

Background:

  • Lorlatinib, a third-generation tyrosine kinase inhibitor, is a first-line treatment for ALK-positive metastatic non-small cell lung cancer.
  • Psychiatric adverse events are frequently observed in patients treated with lorlatinib.
Keywords:
alcohollornatinibmetastatic non-small cell lung cancerpsychiatric adverse eventstrazodone

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