Related Experiment Video
Updated: Jul 16, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
How Common Is Hypercortisolism in Patients With Hypertension? Risk Factors, Epidemiology, and Making a Diagnosis
Omar Al Dhaybi1,2, Deepak L Bhatt1,2
1AHA Comprehensive Hypertension Center, Mount Sinai Fuster Heart Hospital, New York, New York, USA.
Abstract:
Endogenous hypercortisolism (EHC) is an underrecognised and clinically significant contributor to hypertension, particularly resistant hypertension. Once viewed as a rare entity, EHC is now understood as a spectrum of cortisol excess associated with adverse cardiometabolic outcomes and target-organ damage. Recent large-scale studies demonstrate a much higher prevalence of EHC among patients with resistant hypertension and difficult-to-control diabetes, often in the absence of classic Cushingoid features. This review synthesises recent large-scale epidemiological data pertaining to EHC in hypertension, and discusses the various diagnostic modalities, highlighting the need for systematic screening, which may improve outcomes in resistant hypertension.
Related Concept Videos
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hypertension and Regulation of Blood Pressure
Hypertension I: Introduction