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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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Related Experiment Video

Updated: Jul 16, 2026

Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip
08:15

Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip

Published on: February 16, 2024

Integrating Vaginal Microbiome Test Results into Shared Decision Making during In Vitro Fertilization Care.

Rivka Koedooder1, Xu Shan Gao1, Sam Schoenmakers2

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Medical Decision Making : an International Journal of the Society for Medical Decision Making
|July 15, 2026
PubMed
Summary

Couples can understand vaginal microbiome test results for in vitro fertilization (IVF) success. Shared decision-making (SDM) supports couples in deciding whether to proceed or postpone IVF treatment based on these results.

Keywords:
Vaginal microbiomein vitro fertilization (IVF)prognostic testingshared decision makingtreatment postponement

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Last Updated: Jul 16, 2026

Modeling Healthy and Dysbiotic Vaginal Microenvironments in a Human Vagina-on-a-Chip
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Published on: February 15, 2019

Area of Science:

  • Reproductive medicine
  • Microbiome research
  • Decision science

Background:

  • Vaginal microbiota testing predicts in vitro fertilization (IVF) success.
  • Limited therapeutic options exist to improve a low vaginal microbiome profile.
  • Couples face difficult decisions regarding proceeding or postponing IVF treatment.

Purpose of the Study:

  • To examine how couples interpret vaginal microbiome results.
  • To understand postponement decisions within a shared decision-making (SDM) framework.
  • To assess patient involvement in SDM during IVF treatment planning.

Main Methods:

  • The ReceptIVFity test™ classified vaginal microbiomes into high, medium, or low profiles.
  • Physicians used SDM to discuss results and treatment options with couples.
  • Patient-reported outcomes on perceived involvement in SDM were assessed using the SDM-Q-9 questionnaire.

Main Results:

  • A low microbiome profile was identified in 35.4% of participants.
  • Nearly 50% of couples with a low profile chose to postpone IVF treatment.
  • Postponement rates exceeded 80% for couples in later IVF cycles, influenced by insurance and lack of treatment options.

Conclusions:

  • Couples can comprehend and utilize prognostic information from vaginal microbiome tests.
  • SDM effectively facilitates discussions regarding IVF success, timing, and personal values.
  • The ReceptIVFity test™ aids couples in making informed decisions about proceeding or postponing IVF treatment.