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Related Concept Videos

Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent – the...

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Related Experiment Videos

Colchicine in crystal synovitis and beyond.

Fabiola Atzeni1, Elena Bartoloni2, Caterina Antonini2

  • 1Rheumatology Unit, Policlinico Gaetano Martino, University of Messina, Italy.

Clinical and Experimental Rheumatology
|July 15, 2026
PubMed
Summary

Colchicine is a key treatment for crystal-induced inflammatory diseases like gout. This review explores its mechanisms, uses in rheumatic and other disorders, and safe, low-dose application.

Related Experiment Videos

Area of Science:

  • Rheumatology
  • Pharmacology
  • Immunology

Background:

  • Colchicine is a long-standing treatment for crystal-induced inflammatory conditions.
  • Its efficacy is supported by extensive pharmacological and mechanistic data.

Purpose of the Study:

  • To review the pharmacology and mechanisms of colchicine.
  • To summarize its clinical applications in rheumatic disorders and beyond.

Main Methods:

  • This is a narrative review.
  • It synthesizes existing evidence on colchicine's action and use.

Main Results:

  • Colchicine inhibits microtubule functions, neutrophil activation, and inflammasome signaling, reducing interleukin-1β.
  • It also modulates platelet-leukocyte interactions and vascular inflammation.
  • Low-dose regimens and managing drug interactions are crucial due to its narrow therapeutic index.

Conclusions:

  • Colchicine remains vital for gout and calcium pyrophosphate crystal disease (CPPD).
  • Its anti-inflammatory effects are broader, with emerging applications in cardiovascular, dermatological, and other inflammatory conditions.