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Updated: Jul 16, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Three new steroidal alkaloids from the whole plants of Sarcococca ruscifolia
Yong-Jin Ye1, Xiao-Hui Sun2, Gang Ke2
1Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Abstract:
ABETRACTThree previously undescribed steroidal alkaloids, 20α-N,N-dimethylamino-2β-hydroxy-3α-senecioylamino-5α-pregnane (1), 20α-N,N-dimethylamino-2β,4α-dihydroxy-3α-senecioylamino-5α-pregnane (2) and 20α-N,N-dimethylamino-2β,15α-dihydroxy-3α-senecioylamino-5α-pregn-16-ene (3), were isolated from the whole plants of Sarcococca ruscifolia. Their structures were determined through the analysis of physiochemical properties and spectroscopic data. Compound 1 showed a certain inhibitory effect on human glioma U251 cells with an IC50 value of 13.51 μM.
