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Updated: Jul 16, 2026
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Blood Pressure Variability is Associated With Lower Cognitive Function: An Elderly Cohort Study in Hong Kong.
Pingping Jia1,2, Ziyu Hao1, Ruby Yu1,3
1JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
Journal of Clinical Hypertension (Greenwich, Conn.)
|July 15, 2026
Summary
High systolic blood pressure variability (BPV) is linked to an increased risk of mild cognitive impairment (MCI) in older adults. Monitoring BPV may aid in early detection of cognitive decline.
Area of Science:
- Geriatric Health
- Neurology
- Cardiovascular Research
Background:
- Cognitive impairment is a significant health concern for the elderly.
- Blood pressure variability (BPV) is increasingly implicated in cognitive decline via cerebrovascular damage.
Purpose of the Study:
- To examine the prospective association between blood pressure variability (BPV) and cognitive impairment in community-dwelling older adults.
- To investigate if dynamic BP fluctuations contribute to the pathogenesis of cognitive decline.
Main Methods:
- Prospective cohort study in Hong Kong with participants over 55 years old.
- Regular blood pressure (BP) measurements and cognitive function evaluation using the Montreal Cognitive Assessment.
- Machine learning categorized BPV (standard deviation) into high, medium, and low levels; logistic and quantile regression analyses were performed.
Main Results:
- Higher systolic BPV was associated with an increased risk of mild cognitive impairment (MCI) (OR: 1.16; 95% CI: 1.03-1.31).
- Diastolic BPV did not show a significant association with MCI.
- Individuals with high BPV had a 5.6-fold increased risk for MCI compared to those with low BPV, particularly those with lower baseline cognitive function.
Conclusions:
- Higher systolic blood pressure variability is an independent risk factor for MCI in older adults.
- Integrating BPV assessment into routine health monitoring could improve early detection of cognitive decline.
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