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Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...

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Related Experiment Video

Updated: Jul 16, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Myocardial Scar Assessment Using Artificial Intelligence-Powered Contrast-Free MRI: A Prospective Multicenter Study

Qiang Zhang1, Di Zhou2, Patrick Thompson3

  • 1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.

Journal of the American College of Cardiology
|July 15, 2026
PubMed
Summary

Artificial intelligence virtual native enhancement (VNE) accurately detects myocardial scar without contrast agents. This method shows high diagnostic performance and may reduce the need for late gadolinium enhancement (LGE) in routine clinical practice.

Keywords:
artificial intelligencecardiovascular magnetic resonancegadolinium-freemyocardial tissue characterizationvirtual native enhancement

Related Experiment Videos

Last Updated: Jul 16, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Area of Science:

  • Cardiology
  • Medical Imaging
  • Artificial Intelligence

Background:

  • Cardiovascular magnetic resonance (CMR) for myocardial scar detection traditionally requires contrast agents.
  • Artificial intelligence virtual native enhancement (VNE) offers a contrast-agent-free alternative.
  • Clinical validation is essential for integrating VNE into routine practice.

Purpose of the Study:

  • To prospectively evaluate the diagnostic performance of VNE for myocardial scar detection.
  • To assess VNE in a multicenter, blinded, real-world clinical setting.
  • To compare VNE with late gadolinium enhancement (LGE) as the ground truth.

Main Methods:

  • Prospective collection of CMR data from two centers (Leeds and Fuwai).
  • Independent scar assessment using LGE by site teams.
  • Generation of VNE images by an independent team using precontrast data.
  • Blinded assessment of VNE and LGE images by the generating team and four clinical readers.

Main Results:

  • VNE achieved 94.4% accuracy for confident images and 87.5% for all images in diagnosing myocardial infarction.
  • Strong correlation (R=0.90) and close agreement between VNE and LGE for scar quantification.
  • 90.0% agreement between VNE and LGE in identifying infarcted territories.
  • Clinical readers found VNE adequate in 69.7% of cases, achieving 93.7% accuracy comparable to LGE (93.9%).

Conclusions:

  • High-quality VNE images enable accurate myocardial scar quantification without contrast agents.
  • VNE can effectively triage the need for LGE, potentially obviating its use in over two-thirds of chronic myocardial infarction scar assessments.
  • VNE offers a promising, contrast-free approach for myocardial scar assessment without compromising diagnostic accuracy.