[Cutaneous and skeletal manifestations of systemic diseases: SKIBO]

Some diseases, such as neurofibromatosis type 1, Langerhans cell histiocytosis, SAPHO (an acronym for synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome, chronic nonbacterial osteomyelitis, or psoriatic arthropathy, present with manifestations affecting both the skin and the skeleton. Since these diseases can easily be overlooked in diagnostic radiology, an accurate diagnosis relies on the combined evaluation of bone and skin findings. The bidirectional interaction between cutaneous and skeletal tissues is mediated by genetic predispositions as well as immune-inflammatory mechanisms and is summarized under the term SKIBO ("skin-bone interaction"). This CME overview presents the most important SKIBO disorders-which every radiologist should be familiar with-from both radiological and dermatological perspectives, with the aim of raising radiologists' awareness of relevant skin findings in everyday clinical practice.