Copper coordination-assisted magnetic MIP-MOF nanoparticles for highly sensitive matrine electrochemical sensing

Rapid, reliable, and sensitive detection of matrine (MT) is of great significance. This study describes the construction of a highly sensitive MT electrochemical sensor by integrating magnetic molecularly imprinted metal-organic framework nanoparticles (MOFs/MMIPs) with Cu²⁺ coordination. This strategy facilitates the conversion of electrochemical signals, enabling highly sensitive, precise quantitative analysis of MT using anodic stripping voltammetry. Under optimal electrochemical detection conditions, the sensor exhibited good linearity over a concentration range of 4 nM to 4 mM with a detection limit of 2 nM. The sensor's immunity and reproducibility were tested on honey, tea, and cucumber samples, with average recoveries ranging from 96.42% to 104.34%. The experimental results demonstrate that the proposed electrochemical sensor for MT has significant practical implications for the rapid identification of MT remnants in food products.