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Tumor Debulking Plus Chemotherapy in Multiorgan Metastatic Colorectal Cancer

René Adam1, Takashi Matsumoto1, Marc Antoine Allard1

  • 1Hepato-Biliary Center, Department of Surgery, AP-HP Paul Brousse Hospital, Research Unit INSERM U1193, HEPAREG Faculty of Medicine, Paris-Saclay University, Villejuif, France.

JAMA
|July 15, 2026
PubMed
Abstract

No abstract available in PubMed .

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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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