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Related Concept Videos

Electron Microscope Tomography and Single-particle Reconstruction01:07

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Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
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Related Experiment Video

Updated: Jul 17, 2026

Atom Probe Tomography Analysis of Exsolved Mineral Phases
08:14

Atom Probe Tomography Analysis of Exsolved Mineral Phases

Published on: October 25, 2019

Spatial Resolution(s) in Atom Probe Tomography.

Baptiste Gault1,2, Frédéric De Geuser3, Christoph Freysoldt2

  • 1CNRS, INSA Rouen Normandie, Groupe de Physique des Matériaux, UMR 6634, Univ Rouen Normandie, Rouen F-76000, France.

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
|July 15, 2026
PubMed
Summary

Atom probe tomography (APT) offers atomic-scale 3D material analysis. However, reported spatial resolutions are often misleading and context-dependent, necessitating a focus on effective resolution for accurate materials characterization.

Keywords:
atom probe tomographyfield-ion microscopyresolution limitspatial resolution

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Atom Probe Tomography Studies on the Cu(In,Ga)Se2 Grain Boundaries
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Last Updated: Jul 17, 2026

Atom Probe Tomography Analysis of Exsolved Mineral Phases
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Published on: October 25, 2019

Atom Probe Tomography Studies on the Cu(In,Ga)Se2 Grain Boundaries
09:51

Atom Probe Tomography Studies on the Cu(In,Ga)Se2 Grain Boundaries

Published on: April 22, 2013

Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Physics

Background:

  • Atom probe tomography (APT) is frequently cited for its "atomic-scale" 3D material analysis capabilities.
  • Misconceptions persist regarding APT's actual spatial resolution, despite attempts at quantification.
  • Reported depth resolutions (e.g., 20 picometers) are highly context-specific and not universally applicable.

Purpose of the Study:

  • To review methods for defining and measuring spatial resolution in APT and field-ion microscopy (FIM).
  • To clarify the context-dependent nature of APT spatial resolution.
  • To discuss factors affecting resolution and future improvements in spatial accuracy.

Main Methods:

  • Review of existing literature on spatial resolution measurement in APT and FIM for pure metals.
  • Analysis of resolution degradation caused by ion optical devices that enhance mass resolution.
  • Consideration of effective resolution for complex material systems like precipitates in a matrix.

Main Results:

  • Spatial resolution in APT is not a fixed value and varies significantly with material, analysis conditions, and even within a single reconstruction.
  • Specific resolutions achieved in pure metals may not be relevant for broader materials characterization.
  • Ion optical devices aimed at improving mass resolution can negatively impact spatial resolution.

Conclusions:

  • Reported APT spatial resolutions require careful contextualization and should not be generalized.
  • The concept of "effective resolution" is crucial for interpreting APT data, especially in multiphase materials.
  • Future advancements are needed to enhance the spatial accuracy of APT techniques.