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Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line

Wafiya Jibrin1,2, Rod T Mitchell3,4, Federica Lopes1

  • 1School of Medicine, University of Dundee , Dundee, UK.

Reproduction & Fertility
|July 15, 2026
PubMed
Abstract

Insights

Rapamycin did not protect sperm-forming cells in young boys undergoing cancer treatment. Further research is needed to develop medical strategies for preserving male fertility during cancer therapy.

Area of Science:

  • Oncology
  • Reproductive Biology
  • Pharmacology

Background:

  • Cancer treatment in children can lead to infertility.
  • Current medical treatments to protect male fertility are limited.
  • Spermatogonial stem cells are vulnerable to chemotherapy.

Purpose of the Study:

  • To evaluate rapamycin's efficacy in protecting male fertility during cancer treatment.
  • To assess rapamycin's impact on spermatogonial stem cells and sperm development.

Main Methods:

  • The study investigated the use of rapamycin, a drug with known effects on female fertility.
  • Rapamycin's protective effects on male fertility were assessed in the context of cancer treatment.

Main Results:

  • Rapamycin did not prevent the loss or damage of sperm-developing cells.
  • The drug showed no protective effect on male fertility in this study.

Conclusions:

  • Rapamycin is not a viable option for preserving male fertility during cancer treatment.
  • Additional research is necessary to identify effective medical strategies for fertility preservation in young boys undergoing cancer therapy.
Keywords:
chemotherapycisplatininfertilityrapamycin

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