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Aptamer-Modified Nanostructured Particles Exhibiting Sensitive Cell-Scale FRET Enable Precise Pancreatic Cancer

Na He1, Yixi Zhang2, Yuemeng Yang1

  • 1Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China.

Analytical Chemistry
|July 15, 2026
PubMed
Summary

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Early pancreatic cancer (PC) diagnosis is improved using nanostructured magnetic particles (NMPs) to detect circulating tumor cells (CTCs). This novel liquid biopsy method offers high sensitivity and specificity for PC detection.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Oncology

Background:

  • Early-stage pancreatic cancer (PC) diagnosis is hampered by the low sensitivity and specificity of existing biomarkers.
  • Accurate detection of circulating tumor cells (CTCs) is crucial for effective PC diagnosis and management.

Purpose of the Study:

  • To develop and validate a novel platform using nanostructured magnetic particles (NMPs) for highly sensitive and specific quantification of CTCs.
  • To demonstrate the capability of this NMP-based approach for precise diagnosis of PC, distinguishing it from benign pancreatic tumors (BPT) and healthy donors (HD).

Main Methods:

  • Development of NMPs modified with aptamers for enhanced CTC capture and specificity.
  • Utilized Förster resonance energy transfer (FRET) for sensitive CTC detection.

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  • Compared NMPs with smooth magnetic particles (SMPs) to evaluate binding capacity and signal enhancement.

    • Main Results:

    • Achieved an ultralow detection limit of 1 cell/mL for CTCs.
    • Demonstrated superior diagnostic performance in clinical validation: 91.7% sensitivity and 96.6% specificity for PC detection.
    • Achieved an area under the curve (AUC) of 0.957 in ROC analysis, outperforming conventional biomarkers (CA19-9, CEA, CA125).

    Conclusions:

    • The NMP-based CTC detection platform offers significant methodological advancement for tumor liquid biopsy.
    • This approach shows strong potential for accurate clinical diagnosis, monitoring, and evaluation of pancreatic cancer.