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Published on: August 27, 2021
A Bioadhesive Wireless Bioelectric Interface for Single-Dose Prevention of Acute Lung Injury via Piezoelectric
Guopeng Xu1, Mengzhen Liu1, Xusheng Yang1
1State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai200070, China.
Abstract:
Effective management of acute lung injury (ALI) necessitates both prolonged pulmonary retention and precise immune modulation. Here, we report a novel bioadhesive piezoelectric immunomodulator (PNS@PDA), designed to establish a persistent and wireless bioelectric interface for on-demand immunomodulation within the pulmonary microenvironment. Utilizing a mussel-inspired polydopamine (PDA) shell, PNS@PDA exhibits robust tethering to lung parenchyma, achieving a 6.3-fold higher lung accumulation than bare piezoelectric bismuth oxychloride nanosheets (PNS) 32 h postinhalation. Meanwhile, low-intensity ultrasound (1.0 W/cm2) generates on-demand bioelectric cues (>150 mV) that reprogram macrophages from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype by suppressing oxidative stress and NF-κB signaling. In a murine ALI model, a single intranasal dose of PNS@PDA provides potent preventive protection, effectively quenching cytokine storms and restoring alveolar integrity. This work introduces an innovative, on-demand, and wireless biophysical strategy for ALI intervention, offering a generalizable paradigm for the nonpharmacological treatment of acute inflammatory disorders.
