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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
Published on: September 26, 2012
Divergent presentations of anti-GAD autoimmunity: a comparative analysis of two neurodegenerative cases
Matteo Zanovello1, Sofia Pavan1, Angela Petrosino1
1Department of Neuroscience, University of Padova, via Giustiniani 2, Padova, Italy.
Parkinsonism & Related Disorders
|July 15, 2026
Abstract:
We describe two women presenting with cortico-basal syndrome (CBS) and upper motor neuron-motor neuron disease (UMN-MND), respectively, both with high-titre GAD-Abs in serum and CSF. Both patients showed progressive motor impairment with elevated NFL levels. IVIg therapy was administered without meaningful clinical benefit, suggesting neurodegeneration as the primary phenotypic driver.
Keywords:
AutoimmunityCorticobasal syndromeGlutamic acid decarboxylase antibodiesNeurodegenerationUpper motor neuron diseaseMore Related Videos
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