Related Experiment Video

Updated: Jul 17, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Abrine inhibits cervical cancer progression by targeting UGT8

Chunyan Liu1, Changyan Dong1, Luyun Qu1

  • 1Yantai Yuhuangding Affiliated Hospital of Qingdao University, Yantai, Shandong 264000, China.

Tissue & Cell
|July 15, 2026
PubMed
Abstract

Insights

UDP-glycosyltransferase 8 (UGT8) is upregulated in cervical cancer, promoting tumor growth and malignancy. The compound Abrine inhibits cervical cancer progression by targeting UGT8, offering a potential therapeutic strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Understanding cervical cancer molecular mechanisms is crucial for developing new therapeutic targets.
  • Novel therapeutic agents are needed for effective cervical cancer treatment.

Purpose of the Study:

  • To investigate the role of UDP-glycosyltransferase 8 (UGT8) in cervical cancer development.
  • To explore the therapeutic potential of Abrine in targeting UGT8 for cervical cancer treatment.

Main Methods:

  • Analyzed UGT8 mRNA levels in cervical cancer tissues using GEO public microarrays.
  • Detected UGT8 protein expression via immunohistochemical staining.
  • Manipulated UGT8 expression in cervical cancer cell lines and treated with Abrine, assessing effects in vitro and in vivo using xenograft models.

Main Results:

  • UGT8 was highly expressed in cervical cancer tissues, correlating with disease severity.
  • UGT8 overexpression promoted cancer cell proliferation, migration, invasion, and chemoresistance.
  • Abrine inhibited cancer cell progression by down-regulating UGT8 expression and impeding tumor growth in vivo.

Conclusions:

  • UGT8, a key enzyme in galactosylceramide synthesis, is upregulated in cervical cancer and promotes malignancy.
  • Abrine demonstrates therapeutic potential by targeting UGT8 and inhibiting cervical cancer progression.
Keywords:
AbrineAlkaloidsCeramideCervical cancerGlycosylated ceramide

More Related Videos

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity04:20

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity

Published on: February 9, 2024

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...