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Updated: Jul 17, 2026

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
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Published on: February 9, 2020

Lactylation drives oligodendrocyte differentiation and (re)myelination

Aksheev Bhambri1, Lu O Sun2

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Neuron
|July 15, 2026
PubMed
Summary

Lactate fuels myelin repair by promoting oligodendrocyte differentiation. This process involves lactylation, a modification of key enzymes like lactate dehydrogenase A (LDHA), highlighting a metabolic-epigenetic axis crucial for myelin development.

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