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Related Concept Videos

Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Gastric Emptying01:16

Gastric Emptying

Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...

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Related Experiment Video

Updated: Jul 17, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Association between GLP-1-based therapy and small-bowel transit time during capsule endoscopy: a prospective,

Fadi Abu Baker1,2, Melhem Melhem3, Osnat Kalnizki4

  • 1Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Hadera, Israel.

BMJ Open Gastroenterology
|July 15, 2026
PubMed
Summary

Glucagon-like peptide-1 (GLP-1) based therapies are linked to longer small-bowel transit times in capsule endoscopy. Routine discontinuation is not advised, but individual patient assessment is recommended.

Keywords:
ENDOSCOPYGASTRIC EMPTYINGGASTROINTESTINAL MOTILITY

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Studying Murine Small Bowel Mechanosensing of Luminal Particulates
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Related Experiment Videos

Last Updated: Jul 17, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Studying Murine Small Bowel Mechanosensing of Luminal Particulates
10:21

Studying Murine Small Bowel Mechanosensing of Luminal Particulates

Published on: March 18, 2022

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Pharmacology

Background:

  • Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly used for type 2 diabetes and obesity.
  • The effect of GLP-1 based therapies on gastrointestinal transit, particularly small-bowel transit time during capsule endoscopy, is not well established.
  • Understanding these effects is crucial for optimizing capsule endoscopy procedures and interpreting findings in patients on these medications.

Purpose of the Study:

  • To evaluate the association between glucagon-like peptide-1 (GLP-1) based therapy and small-bowel transit time (SBTT) during capsule endoscopy.
  • To compare SBTT, gastric transit time (GTT), capsule completion, and endoscopic findings between patients on GLP-1 based therapy and controls.

Main Methods:

  • A prospective, multicentre, observational study involving adults undergoing small-bowel capsule endoscopy.
  • Patients receiving GLP-1 based therapy (GLP-1 receptor agonists or dual GIP/GLP-1 receptor agonists) were compared with non-exposed controls.
  • Primary outcome was SBTT; secondary outcomes included GTT, capsule completion, and endoscopic findings.

Main Results:

  • Patients on GLP-1 based therapy (n=34) exhibited significantly longer SBTT compared to controls (n=95) (median 311.0 vs 236.0 min; p<0.001).
  • GLP-1 based therapy was independently associated with longer SBTT in multivariable analysis (adjusted β+83 min; p=0.042), after adjusting for age, BMI, diabetes, and indication.
  • No significant differences were observed in GTT, capsule completion rates, or clinically significant endoscopic findings between the groups.

Conclusions:

  • GLP-1 based therapy is associated with prolonged small-bowel transit time during capsule endoscopy.
  • Current findings do not support the routine discontinuation of GLP-1 based therapy before capsule endoscopy.
  • Individualized patient assessment and larger studies are warranted to further evaluate capsule completion and repeat examination rates.