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Orthogonal assembly of hetero-porous structures by reversible adaptation for efficient isomeric separation
Qi Mou1, Changpin Chen1, Xin Li1
1PCFM, GTRCSSTC and GD HPPC Lab, School of Chemistry Sun Yat-sen University, Guangzhou, China.
Nature Communications
|July 15, 2026
Summary
Researchers developed a novel membrane for isomer separation using dynamic chemistry. This highly oriented, multi-porous membrane achieves efficient separation of isomers and enantiomers with high selectivity.
Area of Science:
- Materials Science
- Chemical Engineering
- Separation Science
Background:
- Isomer separation is critical in chemical and biological processes.
- Mixed-matrix membranes (MMMs) offer potential but face compatibility issues.
- Efficient separation requires high permeability and selectivity.
Purpose of the Study:
- To design and construct a highly oriented multi-porous membrane for efficient isomer separation.
- To overcome the limitations of traditional mixed-matrix membranes.
- To create a versatile platform for energy-efficient separations.
Main Methods:
- Orthogonal assembly of hydrogen-bonded macrocycle amphiphiles via dynamic adaptation.
- Formation of lyotropic liquid crystal gels with helical propagation.
- Simultaneous control of immiscible pores for creating aligned chiral nanochannels.
Main Results:
- Achieved precise molecular sieving with a separation factor of 11.46 for constitutional isomers.
- Obtained 92% enantiomeric excess (ee) for enantiomer separation.
- Demonstrated a versatile platform for energy-efficient separations.
Conclusions:
- The developed membrane strategy enables precise molecular sieving.
- This approach provides a versatile platform for chiral resolution and fine chemical purification.
- The dynamic chemistry principle offers a new avenue for biomimetic transport systems.
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