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PAPOLA-mediated hyperactive polyadenylation promotes leukemogenesis and leukemia stem cell self-renewal through

Siyao Guo1,2, Yutong Zou3, Canfeng Zhang2

  • 1Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Nature Cancer
|July 15, 2026
PubMed
Summary

Polyadenylation is key for mRNA function. In acute myeloid leukemia (AML), elevated poly(A) polymerase alpha (PAPOLA) drives cancer growth by altering metabolism, offering a new therapeutic target.

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