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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 17, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Next-generation osteosarcoma models for precision medicine.

Mohamed Saqawa1,2, Miguel Vieira Coelho3, Marta Lourenço3

  • 1National Research Council (CNR), Institute of Science, Technology and Sustainability for Ceramics (ISSMC), Faenza, Italy.

Communications Biology
|July 15, 2026
PubMed
Summary

Tissue engineering and advanced preclinical models offer new ways to study aggressive bone cancer (osteosarcoma). These tools help researchers understand the tumor microenvironment for better drug screening and personalized treatments.

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Area of Science:

  • Oncology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Osteosarcoma (OS) is an aggressive bone cancer with poor outcomes due to metastasis, chemoresistance, and recurrence.
  • Current treatments are insufficient, and OS complexity/heterogeneity hinder understanding.
  • Novel therapies show promise but require better models for study.

Purpose of the Study:

  • To review recent advancements in tissue engineering and preclinical models for studying osteosarcoma.
  • To highlight how these models can improve understanding of the OS tumor microenvironment.
  • To discuss the potential for patient-tailored therapeutic strategies.

Main Methods:

  • Discussion of tissue engineering strategies for OS.
  • Review of 3D in vitro models, organ-on-chip technologies, and in silico models (white-box, black-box, grey-box).
  • Focus on models that replicate the native OS tumor microenvironment.

Main Results:

  • Tissue engineering and advanced preclinical models offer improved tools for OS research.
  • These models facilitate better replication of the OS tumor microenvironment.
  • Development of more representative high-throughput drug screening platforms.

Conclusions:

  • Tissue engineering and advanced preclinical models are crucial for advancing osteosarcoma research.
  • These innovative tools pave the way for developing patient-tailored treatment protocols.
  • Enhanced understanding of OS biology through better models will improve therapeutic outcomes.