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Related Experiment Video

Updated: Jul 17, 2026

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
06:40

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

Published on: June 15, 2018

Dopaminergic Drugs Modulate Resting-State EEG Microstates in Healthy Participants.

Renate de Bock1, Amatya J Mackintosh2, Alexandra Korda3,4

  • 1Department of Psychiatry (UPK), University of Basel, Wilhelm Klein-Strasse 27, Basel, 4002, Switzerland. renate.debock@unibas.ch.

Brain Topography
|July 15, 2026
PubMed
Summary

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Dopamine drugs alter electroencephalography (EEG) microstates in healthy individuals, affecting temporal parameters like duration and occurrence. These findings complicate direct comparisons to patients with psychotic disorders.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Computational Neuroscience

Background:

  • EEG microstate temporal parameters change in psychotic disorders and high-risk individuals.
  • The role of dopamine in these microstate alterations remains unclear.
  • Investigating dopamine's influence can clarify psychosis pathophysiology.

Purpose of the Study:

  • To examine how dopaminergic agents (L-DOPA and haloperidol) affect EEG microstate temporal parameters in healthy adults.
  • To understand the impact of dopamine modulation on brain network dynamics.

Main Methods:

  • A randomized, double-blind, placebo-controlled, cross-over study.
  • Fifty-eight healthy participants received L-DOPA (100 mg), haloperidol (2 mg), or placebo.
  • Resting-state EEG was recorded, and temporal parameters (coverage, duration, occurrence) of microstates A-E were analyzed.
Keywords:
DopamineEEG microstatesElectroencephalogramHaloperidolL-DOPAResting-state

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Last Updated: Jul 17, 2026

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
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Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

Published on: June 15, 2018

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Main Results:

  • Significant drug x microstate class interactions were found for all temporal parameters.
  • L-DOPA and haloperidol altered parameters of microstates B, C, and E compared to placebo.
  • Both drugs increased parameters of microstate D relative to placebo.

Conclusions:

  • Dopaminergic drugs significantly modulate resting-state EEG microstate temporal parameters in healthy individuals.
  • Observed microstate changes under L-DOPA and haloperidol highlight dopamine's role in brain dynamics.
  • Direct extrapolation of these findings to psychotic disorders is complex and requires further investigation.