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Updated: Jul 17, 2026

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A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
Published on: August 24, 2017
Synergy and Synchrony Between Beta-Theta Neurofeedback, Heart Rate Variability Biofeedback and Breathwork Via
1Department of Biomedical Engineering, SR.C, Islamic Azad University, Tehran, Iran. m.zolfagharzadehkermani@iau.ac.ir.
Applied Psychophysiology and Biofeedback
|July 15, 2026
Summary
Combining beta-theta neurofeedback, heart rate variability biofeedback, and box-breathing exercises significantly reduced reaction time in healthy students. This mind-body intervention enhanced electrophysiological and heart rate variability markers.
Area of Science:
- Applied Psychophysiology
- Neuroscience
- Cognitive Psychology
Background:
- The integration of neurofeedback and biofeedback interventions is an emerging area of research.
- Previous studies suggest that interventions targeting electrophysiological activity and physiological regulation can impact cognitive performance.
Purpose of the Study:
- To investigate the effectiveness of a combined training program involving beta-theta neurofeedback, heart rate variability biofeedback, and box-breathing on reaction time.
- To assess the impact of this combined intervention on electrophysiological and heart rate variability markers.
Main Methods:
- Twenty-two students were randomly assigned to three groups: combined training (neurofeedback, biofeedback, box-breathing), box-breathing only, or neurofeedback and biofeedback only.
- Participants underwent 10 training sessions in a pretest-posttest design.
- Reaction time, electroencephalography (EEG) measures, and heart rate variability (HRV) were assessed.
Main Results:
- The group receiving the combined training (beta-theta neurofeedback, HRV biofeedback, box-breathing) showed a significant decrease in visual-recognition-reaction-time compared to the other two groups.
- This group also exhibited significant within-group improvements in EEG measures (beta/theta power ratio, high-beta relative power) and HRV (RMSSD).
Conclusions:
- The simultaneous application of beta-theta neurofeedback, heart rate variability biofeedback, and box-breathing is an effective strategy for reducing reaction time.
- This combined approach facilitates mind-body interaction at a self-aware level, leading to enhanced cognitive performance and physiological regulation.
