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Recent Trends in Tissue Engineering Strategies for Uterine Endometrial Regeneration: a Systematic Review
Afsaneh Nemati1, Firouzeh Sadeghzadeh2,3, Neda Izadi4
1Student Research Committee, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reproductive Sciences (Thousand Oaks, Calif.)
|July 15, 2026
Summary
Tissue engineering offers promising solutions for endometrial regeneration, addressing infertility caused by endometrial injury. Current research highlights hydrogels and scaffolds, with potential for organoids and bioprinting, but clinical evidence is limited.
Area of Science:
- Biomedical Engineering
- Reproductive Medicine
- Regenerative Medicine
Background:
- Endometrial injury significantly contributes to infertility and adverse reproductive outcomes.
- Existing treatments for endometrial repair often fall short in restoring uterine structure and function.
- Tissue engineering presents innovative strategies to address these limitations.
Purpose of the Study:
- To systematically review and evaluate the evidence on tissue engineering strategies for endometrial regeneration.
- To assess the current state and future potential of various tissue engineering approaches in endometrial repair.
Main Methods:
- A systematic literature search was conducted across PubMed, Web of Science, and Scopus databases.
- Studies published between January 2014 and May 2024 were included, resulting in 117 relevant publications.
- Qualitative synthesis was employed due to substantial heterogeneity in study designs and outcome measures.
Main Results:
- Hydrogels and biomaterial scaffolds are the most extensively researched tissue engineering methods for endometrial repair.
- Organoids and 3D bioprinting demonstrate potential for endometrial disease modeling and personalized regenerative therapies.
- Microfluidic systems, though rarely studied, may hold future translational significance for endometrial regeneration.
Conclusions:
- Tissue engineering strategies show considerable promise for advancing endometrial repair and regeneration.
- Clinical translation requires further rigorous human studies to establish safety, efficacy, and long-term durability.
- Current evidence is primarily preclinical, necessitating more clinical trials before widespread adoption.
